" Take responsibility for YOUR OWN body,mind, and spirit, for your own physical, mental, and spiritual well-being."- Mr. C Haymore 

When someone doesn't take care of them self they tend to fall apart in some other aspects like the mind, spirit, or even the own body it self. If you lack in the mind your body won't be health. might have some complications and that could affect the spirit. Maybe the mind more because the person and get depressed. Depression makes the person make feel empty as if you have nothing to think about or as if there shouldn't be nothing to worry about greatly. The way depression affects they body it is telling the mind not eat cause they are not hungry, make the body feel tired more then usual, or even isolate them selves for the family or friends because they feel that it is better to not say anything then to explain. So they build up all the pain and don't bother to look for help because they feel that no one would care about their problems or if they would even help them get over the situation. I think that the part where it first gets affected is the body then the mind and lastly the spirit because a person does not feel the same when they feel different about there body and would feel like they are not even worth it so they stay alone. Slowly it starts to affect the spirit, cause the person to feel realy down or feel no hope at all what so ever.